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Based on their duration of action, they are classified as short-acting or long-acting

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Image Credit: Reshetnikov_art / Shutterstock.com Diabetes management during pregnancy The increased incidence of type 2 diabetes mellitus (T2DM) and increasing maternal age worldwide have led to higher use of insulin, as well as second-line anti-diabetic medications (ADM) during pregnancy

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Targeted pharmacological therapy restores -cell function for diabetes remission

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However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)

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While previous generations GLP-1 agonists (liraglutide) have led to weight loss of 5-10% in most cases, semaglutide can lead to weight loss of up to 20%

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