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These metabolites help support gut barrier integrity, digestive resilience, and healthy metabolic signaling
The most striking protective effects of SGLT2is were a marked reduction in hospitalization for heart failure and a remarkable reduced progression of chronic kidney disease
Additionally, liraglutide shifted polarized macrophage phenotype in vitro from the pro-inflammatory M1 phenotype to the M2 anti-inflammatory phenotype

**Functional Screening:** * The 10,000 designed GLP-1RAs underwent virtual screening based on stability, efficacy, and diversity criteria, which narrowed down the candidates to 60
