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SURPASS-CVOT compared once-weekly tirzepatide with dulaglutide in adults with type 2 diabetes and high cardiovascular risk, showing a 9% relative risk reduction in MACE (HR 0.92, 95% CI 0.83 to 1.01)

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In contrast, in the presence of 16.7 mM glucose, metformin had no effect on incretininduced cAMP production