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But for reproductive-age men who may want children, the standard first-line prescription of TRT deserves reconsideration in light of both the fertility risk it carries and the growing evidence that addressing the metabolic cause may be both safer and more effective

The agency is not aware of any basis for compounding using the salt forms that would meet the FD&C requirements for types of active ingredients that can be compounded

We always want nutrition and lifestyle to be our foundation and sometimes we need a drug

Patients were randomized 1:1:1:1 to survodutide 2.4, 4.8, or 6 mg weekly, or placebo for 48 weeks

Ethics declarations Conflict of interest SC received lecture or consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, MSD, Novo Nordisk