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3.3 Tirzepatide effects: cardiovascular, renal, hepatic, and other metabolic effects of tirzepatide Due to concerns that type 2 diabetes medications increased cardiovascular risk, the FDA issued guidance for pharmaceutical companies to perform cardiovascular outcomes trials for new diabetes medications

For instance, a small study of people in the US, published in the journal JAMA Psychiatry last month, gave a low dose of semaglutide to people with alcohol use disorder each week for nine weeks

"Very disappointingly, no benefit of metformin." Drucker stressed that hes not sharing these findings to quell excitement around GLP-1s, but rather to encourage more study

Immunohistochemical analysis revealed decreased c-Fos activation in the central amygdala and increased GLP-1R expression in the NAc, indicating recruitment of inhibitory control over affective and motivational drug circuits

It is observational, so it can only show associations