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The search strategy combined the Medical Subject Heading (MeSH) terms exenatide OR liraglutide OR semaglutide OR dulaglutide OR albiglutide OR lixizenatide AND diabetes mellitus, type 2 AND a filter to identify RCTs 14

A 2023 review in the Journal of Clinical Endocrinology & Metabolism highlighted that GLP-1s can delay gastric emptying significantly, especially at higher doses or early in treatment.44 Another study found that just over 5% of patients experience gastroparesis and it was more likely when using liraglutide or dulaglutide when compared with semaglutide.45 A 2024 cross-sectional analysis in Pharmaceuticals examined the GI side effects of semaglutide, dulaglutide, liraglutide, and exenatide in over 10,000 adults with T2DM or obesity from the National Institutes of Health All of Us cohort.45 They found that abdominal pain was the most frequently reported GI issue (57.6%), followed by constipation, diarrhea, nausea/vomiting, GI bleeding, gastroparesis, and pancreatitis

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As costs surge and new models emerge, employers are walking a tightrope between compassion and cost as well as between innovation and sustainability