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The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite

Individual risk profiles shape both eligibility and dose escalation timelines

How Semaglutide and Tirzepatide Work for Weight Loss Semaglutide activates GLP-1 receptors in the brain and pancreas, slowing gastric emptying and increasing feelings of fullness after smaller meals

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Thomsen M, Dencker D, Wrtwein G, Weikop P, Egecioglu E, Jerlhag E, Fink-Jensen A, Molander A (2017) The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice