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There are some who shouldnt use Tirzepatide medications at all, including (but not limited to): Patients with an allergy to Tirzepatide medications or any of its ingredients You or a family member has ever had Medullary Thyroid Cancer (MTC) Youve been diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Patients under the age of 18 Patients who are pregnant or breastfeeding Patients who have Type 1 Diabetes You should also be sure to let your health care practitioner know if you: Have a heart condition that raises your heart rate Have stomach or digestive issues Have had inflammation of the pancreas (pancreatitis) Have or have had liver problems Have or have had kidney problems Have ever attempted suicide or had suicidal ideation Use insulin or medications that stimulate insulin production from your pancreas Have or have had conditions related to your pancreas or gallbladder Have retinopathy (diabetic eye disease) Have severe stomach problems or issues with digestion You and your health care practitioner will need to decide if Tirzepatide is a good medication for you or if an alternative medication should be considered