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According to Austin Chen, a registered pharmacist at Express Scripts, Patients should be aware of signs and symptoms of internal bleeding

When prescribed by a licensed provider and used as directed, tirzepatide is considered safe

We always encourage patients to speak with their provider first

Patients sometimes seek compounded tirzepatide because of lower advertised prices or because they cannot obtain a branded prescription

While no randomized controlled trial has specifically studied the tirzepatide-plus-B6 combination, the neurochemical mechanism, specifically the modulation of serotonin and GABA in the brainstem emetic centers, provides a plausible basis for benefit