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In Phase 2 trials, participants began on a low dose and were gradually escalated over several weeks to higher maintenance doses, up to 12 mg weekly
Tirzepatide's NASH trial demonstrated 59% NASH resolution versus 17% placebo, but retatrutide's addition of glucagon-mediated lipolysis may accelerate hepatic fat clearance beyond what dual agonism achieves
Medication Is a Tool, Not the Entire Maintenance Plan GLP-1 medications can be powerful tools, but they should not replace the foundations of long-term metabolic care
The distinction between a research peptide and a medicine is not a matter of degree, it is categorical
Some plans cover Mounjaro for diabetes
