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However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

Furthermore, GLP-1-based medications such as GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, have been shown to improve diabetes control in preclinical and clinical trials with human subjects

Secondary endpoints included the rate of patients with a weight loss of10%, monthly headache days (MHD), the rate of patients with a30% and50% reduction in MHD, visual outcome parameters, and adverse events (AEs)