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In three separate SUSTAIN trials, semaglutide 1 mg conferred a greater weight loss among adults with type 2 diabetes than exenatide 2 mg (Bydureon, AstraZeneca), dulaglutide 1.5 mg (Trulicity, Eli Lilly) and liraglutide 1.8 mg (Saxenda, Novo Nordisk)

Further research, including clinical trials, will be needed to understand whether GLP-1 medicines have a direct effect. Gareth Jones, the director of corporate affairs at the National Pharmacy Association, said: This is a significant study and shows that weight loss treatment may have potential to give important additional therapeutic benefits

Shamsah Amersi, an OB-GYN who specializes in womens health and metabolic medicine, describes it this way: The body responds to consistency, not intensity. In her practice, she starts patients at 0.05 to 0.1 mg of semaglutide weekly and watches for three things: Appetite changes : Most patients notice subtle but real shifts within two to four weeks

This leads to neuroinflammation, vascular occlusion, mitochondrial dysfunction, and the aggregation of pathognomonic proteins, which, in turn, trigger neurodegeneration in the cerebral cortex for AD and the substantia nigra for PD (illustrated in Fig