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Dosage and Administration The recommended dosing schedule is: Start with 0.25mg once weekly for 4 weeks (initiation dose) Increase to 0.5mg once weekly after 4 weeks If additional control is required, increase to 1mg once weekly Maximum recommended dose: 1mg once weekly Administer once weekly on the same day each week, with or without meals

This is due to findings in animal studies where the medication caused an increased risk of thyroid C-cell tumors, including a rare type of thyroid cancer called medullary thyroid carcinoma (MTC)

Br J Pharmacol (2013) 170(7):134962

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