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Further investigations have identified a novel compound, tetrahydrofuran (THF), as a key player indicating the effective PL inhibitor

The characteristic changes of GLP-1 face include 4,5 : Facial volume loss, particularly in the midface Periocular hollowing and periorbital volume depletion Dermal thinning with loss of collagen and elastin fibers Decreased skin elasticity leading to redundant skin folds Accelerated appearance of aging As a result of these facial changes, GLP-1 agonist medications can result in an older, haggard and tired looking appearance

doi:10.1111/j.1365-2982.2007.01079.x Schirra J, Nicolaus M, Woerle HJ, Struckmeier C, Katschinski M, Gke B

[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Bajaj H.S., Gerstein H.C., Rao-Melacini P., Basile J., Colhoun H., Conget I., Cushman W.C., Dagenais G.R., Franek E., Hanefeld M., et al