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Route 2 employs the 40-3 side chain, which is the deprotected version of 15-9

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[16] Weight loss (of greater than 5% of body weight) occurred in 23% of women with axillary node-negative, estrogen-receptor positive breast cancer who received adjuvant tamoxifen (n = 1422) compared with 18% of women who received placebo (n = 1437) following primary surgery in a randomized, double-blind study (the NSABP B-14 study)

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