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Feature Importance for ITE Estimation We applied SHAP values to identify the most influential features contributing to ITE variation

We understand that weight management is a complex process, and what works for one person may not work for another

10.1016/s0140-6736(21)01443-4 49 MarsoS

requires hospitalization Gallbladder Disease (Cholecystitis, Cholelithiasis, Cholangitis): Symptoms : Pain in upper right abdomen Pain may radiate to right shoulder or back Pain often occurs after eating fatty meals Nausea and vomiting Fever and chills Yellowing of skin or eyes (jaundice) Clay-colored stools Dark urine Action Required : Contact healthcare provider immediately May require imaging (ultrasound, CT scan) May require surgical intervention (cholecystectomy) Risk Factors : Rapid weight loss (from any cause increases gallbladder disease risk) Pre-existing gallstones Female sex Age over 40 Obesity paradoxically increases risk Incidence : Occurred more frequently in GLP-1 groups than placebo in clinical trials (approximately 1.5-3% depending on medication and trial) Important Context : Rapid weight loss itself (regardless of method) increases gallbladder disease risk

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