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Importantly, although RETA-w/d restored the tumor transcriptome close to that of Veh, the tumor progression remained relatively blunted, which could be due to factors external to the tumor including systemic metabolic effects, such as insulin concentration, which were only partially restored after RETA-w/d, as discussed above

CRC cases comprise 59.3% colon cancer, 37.9% rectal cancer, and 2.8% anal cancer

6.1 Antioxidant effects GLP-1 receptor agonists exhibit potent antioxidant effects in sepsis by enhancing the expression and activity of key enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, which effectively neutralize ROS that are major mediators of cellular injury during sepsis

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However, in recent times, there has been a significant shortage of Ozempic and its related drug, Wegovy