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Description
This phenomenon occurs in roughly 15-20% of users and stems from multiple factors including dose adjustments, genetic variations in GLP-1 receptor sensitivity, and metabolic adaptation

Over a year, that 60-100 calorie daily deficit represents 6-10 pounds of potential weight loss or, conversely, 6-10 pounds of easier weight regain during a drug holiday

[1] [4] This reduces the risk of hypoglycaemia compared to some other diabetes medications, though this risk increases when combined with insulin or sulfonylureas

95% CI, 0.82-0.92) compared with controls

Semaglutide dosing for weight loss follows a titration model: doses start low and increase at defined intervals to allow the body to adjust while minimizing side effects
