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Mechanically, given the sensitivity of Hippo signaling to physical force, the effect of the fibrotic extracellular matrix (ECM) and the thickened and sclerosed cortex of the polycystic ovaries, which contains more F-actin and collagen, is to downregulate Hippo signaling, resulting in YAP1 over-activation, and thus leading to stromal hypertrophy and over-proliferation of theca cells

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The trial found that participants with obesity alone who got MariTide lost up to 20% of their body weight, on average, after 52 weeks, compared with just 2.6% in the placebo group

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Insider Tip: Disposable needle tips for pens like the ones Saxenda uses require their own separate prescription