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Because levothyroxine is absorbed primarily in the small intestine, and optimal absorption depends on an empty stomach and timely transit through the gastrointestinal tract, any delay in gastric emptying could theoretically affect levothyroxine bioavailability

Variations in physical activity, stress levels, sleep quality, dietary choices, and hydration throughout the week can all impact appetite, energy levels, and blood glucose control

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In the early stages of HT (normal thyroid hormones TSH and thyroxine), the effects of hypothyroidism are not prevalent

If your provider can use a non-systemic option for your condition, that may avoid the interaction entirely