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It was conducted and reported per the preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 recommendations [15] (see Additional File - Supplementary Material 1)

Future research urgently requires rigorously designed, well-sample-sized and longer follow-up period randomized double-blind trials, especially in the elderly population

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GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response