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Whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on extrahepatic tissues, or whether their action is direct, i.e., through activating GLP-1R on the hepatocytes, is still a controversial issue

Long half-life (~6 days)

Fatty liver: Can lead to fatty liver disease, which may progress to liver dysfunction, cirrhosis, or require liver transplant

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Novo Nordisk is taking another step to expand access to our innovative medicines by lowering the self-pay price for GLP-1 treatments and launching an introductory offer of $199 for eligible new patients