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In the SURMOUNT-1 program summarized in the EMA product information, tirzepatide produced mean body-weight reductions of 16.0%, 21.4% and 22.5% at 72 weeks across the 5 mg, 10 mg and 15 mg groups, versus 2.4% with placebo

It mimics the action of GLP-1 hormone to suppress appetite and maintain blood sugar levels

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Recent negative outcomes from the pivotal phase 3 EVOKE and EVOKE+ trials, which demonstrated no clinical benefit of oral semaglutide in patients with early AD, have resulted in a notable translational paradox