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Diabetes Obes Metab (2018) 20(2):35261

Clinical Nuclear Medicine

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Inhibition of PKA activity by PKI did not alter the protective effects of exendin-4 on MG-induced apoptosis ( Figure 3D ), MG-induced mRNA expression of COX5a, MCU, PGC1, and DRP1 ( Figure 3E ), and MG-induced mRNA and protein expressions of Bad and Bax ( Figures 3F, G , respectively)

Although these three types of cells each have distinct functions, it is more important to note that the somatostatin, glucagon, and insulin they secrete work together through mutual regulation and feedback mechanisms to maintain blood glucose balance and overall metabolic homeostasis