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Description
Oral GLP-1 therapies can expand the market, but they may not completely overtake injectables
Exendin4 exerts osteogenic actions in insulinresistant and type 2 diabetic states
For example, in the study we cited where berberine went up against metformin, 35% of subjects had significant gastrointestinal upset when taking the 1,500 mg/day dose (three capsules worth)
This corresponded to an average (SD) GCGR occupancy of 11.2 (14.4) % at a dose of 0.2 mg SAR425899
The goal is to spark dramatic change over the long run
