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The ARRs for participants with UACR 300 mg/g were 2.68%, 0.91% and 3.24%, respectively

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Moreover, a variety of plasma and CSF biomarkers are employed as pharmacodynamic biomarkers to determine the effects of semaglutide on peripheral inflammation, core biomarkers of AD, oxidative stress, vascular integrity, synaptic function, and BBB integrity

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These findings highlight the critical role of GLP-1 analogues in modulating immune responses within atherosclerotic lesions, supporting their potential to reduce cardiovascular risk beyond their effects on glycaemic control (Table 1