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Over time, as liver, adipose and skeletal muscle tissues develop a reduced insulin sensitivity, insulin secretion from pancreatic -cells is no longer suffice in maintaining blood glucose levels within the normal homeostatic range, resulting in hyperglycemia (Yamada et al., 2006)

Tirzepatide has been recognized for its ability to reduce appetite , consequently impacting body weight

However, clinically significant HbA1c improvements generally become apparent at 12 weeks, with maximum glycemic effects observed at 24 to 40 weeks