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A recent review in Fertility and Sterility emphasized how GLP-1s are being considered as part of preconception care for women with PCOS and obesity

Clinical impact of Glucagon like peptide-1 receptor analogs on the complications of obesity

Dehydration from severe nausea, vomiting, or diarrhea can cause acute kidney injury, with or without existing kidney disease, 140 as well as heart palpitations, so efforts should be made to prevent dehydration

Reducing dosing frequency from weekly to every two weeks, which cuts total drug exposure in half, only reduced weight loss from approximately 17% to approximately 12%

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