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Future randomised controlled trials should specifically evaluate the effectiveness of novel AOMs for long-term weight management in older adults with obesity, carefully considering the impact on body composition and functional ability, as well as health economics.

Are managing diabetes, especially if using insulin or other medications

This compounded medication mimics the GLP1 hormone, which regulates blood sugar levels, appetite, and digestion

Semaglutide (SEM) is a recently introduced GLP-1 receptor agonist (GLP-1RA) for the treatment of obesity and type 2 diabetes mellitus by mitigating insulin resistance

Secondary outcomes included time below and above the therapeutic range and INR variability