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During clinical trials, 1.9% of patients reported heartburn symptoms on the 1 mg doses of semaglutide

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Despite their importance, GLP-1RAs were, until recently, only available for subcutaneous administration, which may have contributed to lower usage rates versus orally available therapies (i.e., SGLT2is and DPP-4 inhibitors) [6, 7, 34,35,36,37]

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