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When combined with medications such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors or specific insulin formulations that exhibit complementary effects on weight regulation, combination therapy has the potential to significantly enhance weight loss outcomes and improve body composition in patients with co-morbid type 2 diabetes and obesity

The lineup includes the Wegovy pill (oral semaglutide, FDA-approved December 2025, launched January 2026, the first FDA-approved oral GLP-1 for weight loss in adults), the Wegovy pen (injectable semaglutide 2.4 mg), Zepbound (tirzepatide via LillyDirect), and Ozempic (off-label for weight loss)

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