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doi: 10.1038/oby.2009.158, PMID: [DOI] [PubMed] [Google Scholar] 62

202 Management of these mood disorders involves psychological interventions such as cognitive behavioral therapy (CBT) and pharmacotherapy with antidepressants, considering their metabolic effects

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If phase 3 results remain positive, regulatory submissions may begin in 2026, meaning orforglipron could become available in late 2026 or 2027, depending on MHRA and NICE approval timelines
