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Realistic 2026 Results: What the Data Shows Reduced calorie intake due to fewer meals Improved insulin sensitivity Increased fat burning during fasting periods However, IF does not directly suppress appetite, which is why many people struggle with hunger during fasting hours

Innovative designs incorporating active comparators, adaptive frameworks, and biomarker-driven endpoints (e.g., CSF/serum NfL, p-tau, microglial PET, synaptic markers) will be critical to generate interpretable efficacy signals

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