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As DiMarchi points out, 'What you're trying to do is take two individual keys and make a master key that is every bit as effective as the two individual parts.' To their surprise they noticed that mice lost more weight when injected with a balanced dual agonist than when given one more centred on GLP-1

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Young: Particularly after, like, a drug treatment, is gonna be fat instead of muscle mass because, obviously, right, like, maybe with physical exercise, youre still maintaining those good behaviors a little bit more with exercising more regularly, or same with eating patternsmaybe youre still kind of, like, eating a little bit better than you were before, even if you fully stop a diet or, like, an intensive training regimen for exercise

doi: 10.3390/jcm8040488

Nearly every participant maintained the same BMI following the reduced frequency