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The mean LVEF was 33.7% and 35.4% in the liraglutide and placebo groups, respectively, and 60% of patients had ischaemic heart disease

The effects became measurable after 20 weeks of treatment, providing objective biochemical confirmation of what patients reported experiencing

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This flexibility enabled regulators to tailor safety monitoring based on actual risk profiles observed during drug development, facilitating the approval of drugs like GLP-1R agonists for broader therapeutic use, including in non-diabetic populations with Cardiovascular-Kidney-Metabolic (CKM) Syndrome

Br J Pharmacol 166 , 121136, (2012)