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Microglial activation plays a critical role in the pathogenesis of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyidine- (MPTP-) induced Parkinson's disease model and human Parkinson's disease [27]

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Wong C, et al

While early findings and theoretical models suggest these medicines may influence dopamine-mediated reward pathways, there are no large-scale clinical trials confirming their effectiveness in treating substance dependence

First, the route of cannabis administration (oral, smoked, or vaporized) alters THC pharmacokinetics, as well as its cardiorespiratory and subjective effects 4952

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