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The phosphorylated JAKs, especially JAK2, in turn stimulates the phosphorylation of three residues on the intracellular domain of LepRb (Tyr985, Tyr1077 and Tyr1138), and recruits distinct downstream signaling molecules to a leptin-specific signaling pathway to exhibit diverse physiological functions [84, 86]

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Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial

A new pharmacological approach: The incretin effect First of all, it should be noted that although they are best known to the public by their trade names (Ozempic, Mounjaro), it is the generic names of these drugs (semaglutide and tirzepatide, respectively) that are used in the scientific literature and we will therefore use this nomenclature throughout this article