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The data in Figure 13 summarizes the energetic contributions of GLP-1R residues, along with critical, or more precisely, the hotspot amino acids that contribute to GLP-1R activation and insulin exocytosis
Supporting Study: Day, J
A Phase III trial of Exenatide in PD (NCT4232969) found that Exenatide was without clinical benefit [56]
Similarly the weight loss seen with Exenatide and some other early GLP-1 drugs was thought too limited to win approval for the treatment of obesity (Gilbert, Rosenthal, March 2024)
DOI: 10.1001/jamaophthalmol.2025.1455
