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In ovarian granulosa cells, hypermethylation of the steroidogenic enzyme cytochrome P450 family 19 subfamily A member 1 (CYP19A1) promoter reduces estrogen biosynthesis while relatively increasing androgen production, thereby exacerbating hyperandrogenemia (52)

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Silva, A

Non-nave Vietnamese male cynomolgus monkeys (Nafovanny/KHI Group

Clinical Endocrinology, 99 (4), 401408