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J Am Coll Cardiol S0735109724104147

13 Twincretins: Dual GLP-1 and GIP Receptor Agonists Research on incretin-based therapies for T2DM has seen an exponential increase in the past three decades

The Accelerated Approval is based on part 1 of the ESSENCE trial that showed that at 72 weeks, 36.8% of people treated with Wegovy 2.4 mg achieved improvement in liver fibrosis with no worsening of steatohepatitis compared to 22.4% of individuals who received placebo

Despite these adverse caveats, both diabetic mice and non-human primates respond well to treatment with an antagonistic monoclonal GcgR antibody that corrects hyperglycemia

Overall, the breadth of cutaneous manifestations was also notable, reinforcing that these medications can affect more than just metabolic pathways
