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Description
Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical trial

Biochem Biophys Res Commun (2023) 671:20514

Using the same protocol as in Figure 1A, we administered vehicle or liraglutide to fasted control mice and mice lacking the GLP-1R in neurons targeted by the Wnt1 - Cre2 driver (Wnt1 Glp1r/ ) or in glutamatergic neurons (Vglut2 Glp1r/ )

The medication produced dose-dependent improvements in both glycaemic control and body weight

However, risk for diabetic retinopathy was significantly higher among the GLP-1 drugs users than nonusers (aHR = 1.49
