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Due to the way semaglutide works, the medication may lead to gastrointestinal (GI)-related side effects

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Rushing through the titration schedule often means more severe GI symptoms, worse adherence, and sometimes temporary discontinuation, which ultimately slows progress

21,22 The combination of allosteric activation and phosphorylation at Thr172 leads to a greater than 1,000-fold increase in kinase activity in cell-free assays, 23 although the changes under physiological conditions are likely much smaller

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