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But it takes time to achieve a new normal

In the early stages of T2DM, insulin demand increases due to peripheral insulin resistance, when the body compensates by stimulating islet cells to release more insulin, thereby maintaining blood glucose stability

Specifically, GLP-1 receptor activation decreased anticipatory food reward responses in the OFC, putamen, left insula, and left amygdala, while it increased consummatory reward responses in the right OFC, putamen, left insula, left amygdala, and right caudate (van Bloemendaal et al., 2015a)

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A high fat diet enriched with sea cucumber gut powder provides cardio-protective and anti-obesity effects in C57BL/6 mice