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4) Side-effect prevention as a standard, not an afterthought Most I had to stop stories are preventable

Compared with placebo, semaglutide 2.0 mg (risk ratio = 7.73 [95% CI 5.62, 10.63]) and tirzepatide 15 mg (risk ratio = 7.01 [95% CI 5.73, 8.57]) were the most efficacious in achieving an HbA 1c target of 48 mmol/mol (6.5%) (ESM Table 9)

It is the reason once-weekly dosing works at all

Patients who implement structured maintenance strategies , including gradual tapering, exercise, dietary habits, and monitoring, retain more of their weight loss than those who stop abruptly
