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Description
Whilst GLP-1 receptor agonists primarily work by enhancing insulin secretion rather than directly improving insulin sensitivity at the cellular level, the associated weight loss that often occurs with these medications can lead to secondary improvements in insulin resistance

In the absence of head-to-head randomised controlled trials comparing the two drugs, researchers used the health records and pharmacy dispensing data to analyse weight loss trajectories in 9,193 patients receiving Mounjaro and the same number of closely matched patients receiving Ozempic
It should not be this difficult to get basic treatment information

Checking tests like hemoglobin A1c, fasting glucose, cholesterol, and liver function give a view of whats happening in the body

These were not measured so all we can do is speculate on the causes of lean body mass loss in the semaglutide trials
