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The combination of tirzepatide and metformin is most appropriate for specific patient populations where both medications' complementary mechanisms address clinical needs

Only for diabetes, obstructive sleep apnea (Zepbound), or cardiovascular and MASH indications (Wegovy)

Wegovy is started at a lower dose (0.25mg) and gradually increased over several weeks to the maintenance dose of 2.4mg to minimise gastrointestinal side effects

Supports balanced blood sugar

Studies and meta-analyses have revealed that postprandial GLP-1 levels increase after the Roux-en-Y gastric bypass and sleeve gastrectomy, but fasting GLP-1 levels do not increase significantly