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In rare cases, medications may trigger systemic inflammation, which may also affect the ocular surface and contribute to dry eye symptoms

In our study, although the use of GLP-1 RAs was associated with a modest increase in the rate of incident DR (0.2% increase) over 2 years, the absolute number of new DR diagnoses was low at 2.7%, likely below the expected annual incidence in US patients with T2D

The theory was based on historical usage of bitter foods for appetite regulation across various cultures

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However, the added agonism of GIPR seems to have a more positive impact on weight loss