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This article examines the relationship between GLP-1 therapy and heart rate, explores the underlying mechanisms, reviews cardiovascular safety data, and provides guidance on when to seek medical advice

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Seek medical advice if: Changes in libido are persistent (lasting beyond 34 months) or severe enough to cause significant distress or relationship difficulties You experience other new symptoms alongside reduced libido, such as persistent fatigue, mood changes, difficulty achieving or maintaining erections (in men), vaginal dryness or pain (in women), or changes in menstrual patterns You have concerns about your medication or are considering stopping Mounjaro due to sexual side effectsnever discontinue prescribed medication without medical guidance You develop symptoms of depression or anxiety , as mental health significantly impacts sexual function and requires appropriate assessment and support You notice signs of hormonal imbalance , such as unexpected hair loss, skin changes, or breast tenderness You experience menstrual irregularities or have concerns about contraceptive effectiveness while using Mounjaro Your GP can conduct a thorough assessment, which may include reviewing your medication regimen (as other medicines can affect libido), checking relevant blood tests (including thyroid function, HbA1c, and in men with symptoms of hypogonadism, morning testosterone levels), and screening for depression or anxiety

Another mechanism that might better explain the finding of residual gastric content under these conditions (illustrated in Fig