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There was no change in TBR (reported as the percentage of time spent with interstitial glucose values below 70 mg/dL), whereas a severe hypoglycemic episode ( n = 1) and severe constipation ( n = 1) led to tirzepatide discontinuation in two patients

MRI-based body composition analysis revealed that subjects in the pemvidutide groups experienced an average lean mass loss of only 21.9%, meaning that 78.1% of the weight loss was attributable to fat