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GIP and Pancreatic -Cells The secretion of insulin from pancreatic -cells in response to glucose involves a rise in the intracellular ATP/adenosine diphosphate (ADP) ratio, leading to cell depolarization through ATP-sensitive K + (K ATP ) channels [77], which then triggers the entry of Ca 2+ ions via voltage-dependent Ca 2+ channels (VDCCs) [78-80]

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& Takada, M

9 Receptors have been identified in a number of tissues, including the GI tract, pancreas, brain, lung, and kidney, but their roles are not well understood across all organ systems